Endocrine Abstracts

Despite the recognized importance of thyroid hormones (TH) for normal brain development, little is known about the critical molecular events underlying this role. We investigated the molecular basis of TH action on the developing brain by: (1) comparing genome-wide gene expression patterns in the cerebellum of euthyroid, hypothyroid and hyperthyroid juvenile mice treated with 6-propyl thiouracil or mercapto-methylimidazole /perchlorate using DNA microarrays; and (2) investigat...